Probióticos encapsulados por gelación iónica: Aliados blindados
DOI:
https://doi.org/10.59741/agraria.v23i3.766Palabras clave:
Probióticos, Gelación iónica, Encapsulación, AlginatoResumen
La encapsulación por gelificación iónica es una técnica que protege y preserva diversos microorganismos de interés, incluidos los probióticos. Su función consiste en formar una barrera que ayuda a mantener su viabilidad durante el procesamiento de los alimentos y frente a las condiciones adversas del sistema digestivo, favoreciendo así su llegada al intestino delgado y al colon, donde pueden ejercer efectos beneficiosos para el consumidor. Además, se trata de un método económico, sencillo y seguro, lo que lo hace atractivo para la industria alimentaria en el desarrollo de alimentos funcionales. Su aplicación puede contribuir a fomentar el consumo de probióticos, favorecer el equilibrio de la microbiota intestinal y mejorar la digestión.
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Referencias
Afzaal, M. et al. (2020) “Encapsulation of Bifidobacterium bifidum by internal gelation method to access the viability in cheddar cheese and under simulated gastrointestinal conditions,” Food Science & Nutrition, 8(6), pp. 2739–2747. Available at: https://doi.org/10.1002/fsn3.1562.
Asgari, S. et al. (2020) “Polymeric carriers for enhanced delivery of probiotics,” Advanced Drug Delivery Reviews, 161–162, pp. 1–21. Available at: https://doi.org/10.1016/j.addr.2020.07.014.
Aureli, P. et al. (2011) “Probiotics and health: An evidence-based review,” Pharmacological Research, 63(5), pp. 366–376. Available at: https://doi.org/10.1016/j.phrs.2011.02.006.
Baral, K.C. et al. (2021) “Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology,” International Journal of Nanomedicine, Volume 16, pp. 7535–7556. Available at: https://doi.org/10.2147/IJN.S337427.
Bustos, A.Y. et al. (2025) “Recent Advances in the Understanding of Stress Resistance Mechanisms in Probiotics: Relevance for the Design of Functional Food Systems,” Probiotics and Antimicrobial Proteins. Springer, pp. 138–158. Available at: https://doi.org/10.1007/s12602-024-10273-9.
Chavarri, M., Maranon, I. and Carmen, M. (2012) “Encapsulation Technology to Protect Probiotic Bacteria,” Probiotics. InTech. Available at: https://doi.org/10.5772/50046.
Facioni, M.S. et al. (2020) “Nutritional management of lactose intolerance: the importance of diet and food labelling,” Journal of Translational Medicine, 18(1), p. 260. Available at: https://doi.org/10.1186/s12967-020-02429-2.
Farahmand, A. et al. (2024) “Double protection of probiotics in alginate hydrogel through emulsification incorporated with freeze drying and coaxial wet-electrospraying: Survivability and targeted delivery,” LWT, 204. Available at: https://doi.org/10.1016/j.lwt.2024.116459.
Gharibzahedi, S.M.T. and Smith, B. (2021) “Legume proteins are smart carriers to encapsulate hydrophilic and hydrophobic bioactive compounds and probiotic bacteria: A review,” Comprehensive Reviews in Food Science and Food Safety, 20(2), pp. 1250–1279. Available at: https://doi.org/10.1111/1541-4337.12699.
Gómez-Gaete, C. et al. (2024) “Revolutionizing fruit juice: exploring encapsulation techniques for bioactive compounds and their impact on nutrition, flavour and shelf life,” Food Production, Processing and Nutrition. BioMed Central Ltd. Available at: https://doi.org/10.1186/s43014-023-00190-9.
Hill, C. et al. (2014) “Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic,” Nature Reviews Gastroenterology and Hepatology, 11(8), pp. 506–514. Available at: https://doi.org/10.1038/nrgastro.2014.66.
Kelly, J.R. et al. (2015) “Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders,” Frontiers in Cellular Neuroscience, 9. Available at: https://doi.org/10.3389/fncel.2015.00392.
Kiepś, J. and Dembczyński, R. (2022) “Current Trends in the Production of Probiotic Formulations,” Foods. MDPI. Available at: https://doi.org/10.3390/foods11152330.
Latif, A. et al. (2023) “Probiotics: mechanism of action, health benefits and their application in food industries,” Frontiers in Microbiology, 14. Available at: https://doi.org/10.3389/fmicb.2023.1216674.
López-Yerena, A. et al. (2024) “Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease,” Nutrients, 17(1), p. 52. Available at: https://doi.org/10.3390/nu17010052.
Mackowiak, P.A. (2013) “Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life,” Frontiers in Public Health, 1. Available at: https://doi.org/10.3389/fpubh.2013.00052.
Mendonça, A.A. et al. (2023) “Journey of the Probiotic Bacteria: Survival of the Fittest,” Microorganisms. MDPI. Available at: https://doi.org/10.3390/microorganisms11010095.
Mörkl, S. et al. (2020) “Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry,” Current Nutrition Reports, 9(3), pp. 171–182. Available at: https://doi.org/10.1007/s13668-020-00313-5.
Mosquera Vivas, E., Ayala Aponte, A. and Serna Cock, L. (2023) “Importancia de la encapsulación de probióticos: gelificación iónica y coacervación compleja como técnicas prometedoras para uso alimentario,” Biotecnología en el Sector Agropecuario y Agroindustrial, 22(1), pp. 105–123. Available at: https://doi.org/10.18684/rbsaa.v22.n1.2024.2223.
Ortiz-Romero, N. et al. (2021) “Avances en las investigaciones sobre la encapsulación mediante gelación iónica: una revisión sistemática,” TecnoLógicas, 24(52), p. e1962. Available at: https://doi.org/10.22430/22565337.1962.
Afzaal, M. et al. (2020) “Encapsulation of Bifidobacterium bifidum by internal gelation method to access the viability in cheddar cheese and under simulated gastrointestinal conditions,” Food Science & Nutrition, 8(6), pp. 2739–2747. Available at: https://doi.org/10.1002/fsn3.1562.
Asgari, S. et al. (2020) “Polymeric carriers for enhanced delivery of probiotics,” Advanced Drug Delivery Reviews, 161–162, pp. 1–21. Available at: https://doi.org/10.1016/j.addr.2020.07.014.
Aureli, P. et al. (2011) “Probiotics and health: An evidence-based review,” Pharmacological Research, 63(5), pp. 366–376. Available at: https://doi.org/10.1016/j.phrs.2011.02.006.
Baral, K.C. et al. (2021) “Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology,” International Journal of Nanomedicine, Volume 16, pp. 7535–7556. Available at: https://doi.org/10.2147/IJN.S337427.
Bustos, A.Y. et al. (2025) “Recent Advances in the Understanding of Stress Resistance Mechanisms in Probiotics: Relevance for the Design of Functional Food Systems,” Probiotics and Antimicrobial Proteins. Springer, pp. 138–158. Available at: https://doi.org/10.1007/s12602-024-10273-9.
Chavarri, M., Maranon, I. and Carmen, M. (2012) “Encapsulation Technology to Protect Probiotic Bacteria,” Probiotics. InTech. Available at: https://doi.org/10.5772/50046.
Facioni, M.S. et al. (2020) “Nutritional management of lactose intolerance: the importance of diet and food labelling,” Journal of Translational Medicine, 18(1), p. 260. Available at: https://doi.org/10.1186/s12967-020-02429-2.
Farahmand, A. et al. (2024) “Double protection of probiotics in alginate hydrogel through emulsification incorporated with freeze drying and coaxial wet-electrospraying: Survivability and targeted delivery,” LWT, 204. Available at: https://doi.org/10.1016/j.lwt.2024.116459.
Gharibzahedi, S.M.T. and Smith, B. (2021) “Legume proteins are smart carriers to encapsulate hydrophilic and hydrophobic bioactive compounds and probiotic bacteria: A review,” Comprehensive Reviews in Food Science and Food Safety, 20(2), pp. 1250–1279. Available at: https://doi.org/10.1111/1541-4337.12699.
Gómez-Gaete, C. et al. (2024) “Revolutionizing fruit juice: exploring encapsulation techniques for bioactive compounds and their impact on nutrition, flavour and shelf life,” Food Production, Processing and Nutrition. BioMed Central Ltd. Available at: https://doi.org/10.1186/s43014-023-00190-9.
Hill, C. et al. (2014) “Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic,” Nature Reviews Gastroenterology and Hepatology, 11(8), pp. 506–514. Available at: https://doi.org/10.1038/nrgastro.2014.66.
Kelly, J.R. et al. (2015) “Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders,” Frontiers in Cellular Neuroscience, 9. Available at: https://doi.org/10.3389/fncel.2015.00392.
Kiepś, J. and Dembczyński, R. (2022) “Current Trends in the Production of Probiotic Formulations,” Foods. MDPI. Available at: https://doi.org/10.3390/foods11152330.
Latif, A. et al. (2023) “Probiotics: mechanism of action, health benefits and their application in food industries,” Frontiers in Microbiology, 14. Available at: https://doi.org/10.3389/fmicb.2023.1216674.
López-Yerena, A. et al. (2024) “Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease,” Nutrients, 17(1), p. 52. Available at: https://doi.org/10.3390/nu17010052.
Mackowiak, P.A. (2013) “Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life,” Frontiers in Public Health, 1. Available at: https://doi.org/10.3389/fpubh.2013.00052.
Mendonça, A.A. et al. (2023) “Journey of the Probiotic Bacteria: Survival of the Fittest,” Microorganisms. MDPI. Available at: https://doi.org/10.3390/microorganisms11010095.
Mörkl, S. et al. (2020) “Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry,” Current Nutrition Reports, 9(3), pp. 171–182. Available at: https://doi.org/10.1007/s13668-020-00313-5.
Mosquera Vivas, E., Ayala Aponte, A. and Serna Cock, L. (2023) “Importancia de la encapsulación de probióticos: gelificación iónica y coacervación compleja como técnicas prometedoras para uso alimentario,” Biotecnología en el Sector Agropecuario y Agroindustrial, 22(1), pp. 105–123. Available at: https://doi.org/10.18684/rbsaa.v22.n1.2024.2223.
Ortiz-Romero, N. et al. (2021) “Avances en las investigaciones sobre la encapsulación mediante gelación iónica: una revisión sistemática,” TecnoLógicas, 24(52), p. e1962. Available at: https://doi.org/10.22430/22565337.1962.
Petrariu, O.-A. et al. (2024a) “Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases,” Frontiers in Microbiology, 14. Available at: https://doi.org/10.3389/fmicb.2023.1296447.
Petrariu, O.-A. et al. (2024b) “Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases,” Frontiers in Microbiology, 14. Available at: https://doi.org/10.3389/fmicb.2023.1296447.
Rafael, E.G.-C., Fredy, C.-C. and Arnulfo, T.-D. (2017) “Protection of Lactobacillus acidophilus under in vitro gastrointestinal conditions employing binary microcapsules containing inulin,” African Journal of Biotechnology, 16(3), pp. 132–138. Available at: https://doi.org/10.5897/AJB2016.15700.
Rezagholizade-shirvan, A. et al. (2024) “Bioactive compound encapsulation: Characteristics, applications in food systems, and implications for human health,” Food Chemistry: X. Elsevier Ltd. Available at: https://doi.org/10.1016/j.fochx.2024.101953.
Saeed, M. et al. (2024) “Viability of Free and Alginate–Carrageenan Gum Coated Lactobacillus acidophilus and Lacticaseibacillus casei in Functional Cottage Cheese,” ACS Omega, 9(12), pp. 13840–13851. Available at: https://doi.org/10.1021/acsomega.3c08588.
dos Santos, A.P., Zambianchi, J.K. and Benegra, M. (2025) “Lactobacillus helveticus Encapsulated by Ionic Gelation with Sodium Alginate: A Controlled Release Study in Peanut Butter,” ACS Food Science & Technology, 5(5), pp. 1894–1901. Available at: https://doi.org/10.1021/acsfoodscitech.5c00063.
Sarita, B. et al. (2024) “A comprehensive review of probiotics and human health-current prospective and applications,” Frontiers in Microbiology. Frontiers Media SA. Available at: https://doi.org/10.3389/fmicb.2024.1487641.
Sebastián Domingo, J.J. (2017) “Revisión del papel de los probióticos en la patología gastrointestinal del adulto,” Gastroenterología y Hepatología, 40(6), pp. 417–429. Available at: https://doi.org/10.1016/j.gastrohep.2016.12.003.
Shanuke, D.S. et al. (2025) “Co-Encapsulation of Probiotics and Prebiotics: Techniques and Applications in Food Fortification,” Food Science and Nutrition. John Wiley and Sons Inc. Available at: https://doi.org/10.1002/fsn3.70426.
Sibanda, T. et al. (2024) “Bifidobacterium species viability in dairy-based probiotic foods: challenges and innovative approaches for accurate viability determination and monitoring of probiotic functionality,” Frontiers in Microbiology. Frontiers Media SA. Available at: https://doi.org/10.3389/fmicb.2024.1327010.
de Souza Simões, L. et al. (2017) “Micro- and nano bio-based delivery systems for food applications: In vitro behavior,” Advances in Colloid and Interface Science, 243, pp. 23–45. Available at: https://doi.org/10.1016/j.cis.2017.02.010.
Sridhar, K. et al. (2022) Natural sources and encapsulating materials for probiotics delivery systems: Recent applications and challenges in functional food development.
Starovoitova, S.O. et al. (2022) “MODERN ASPECTS OF PROBIOTIC MICROORGANISMS’ MICROENCAPSULATION,” Mikrobiolohichnyi Zhurnal. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine, pp. 72–85. Available at: https://doi.org/10.15407/microbiolj84.05.072.
Stavropoulou, E. and Bezirtzoglou, E. (2020) “Probiotics in Medicine: A Long Debate,” Frontiers in Immunology, 11. Available at: https://doi.org/10.3389/fimmu.2020.02192.
Tan, L.L., Ang, K.L. and Loo, S.C.J. (2023) “Alginate encapsulation improves probiotics survival in carbonated sodas and beers,” PLOS ONE, 18(3), p. e0283745. Available at: https://doi.org/10.1371/journal.pone.0283745.
Tolve, R. et al. (2016) “Encapsulation of health-promoting ingredients: applications in foodstuffs,” International Journal of Food Sciences and Nutrition, 67(8), pp. 888–918. Available at: https://doi.org/10.1080/09637486.2016.1205552.
Torabi-Rahvar, P. et al. (2025) “Efficient production of cell-encapsulated microgels using flicking technique,” Journal of Drug Delivery Science and Technology, 108, p. 106921. Available at: https://doi.org/10.1016/j.jddst.2025.106921.
Valero-Cases, E. et al. (2025) “Design of Multi-Component Beads (Alginate/Xanthan/Glycerol): Influence of Polymer Concentration on Lactobacillus acidophilus Viability and Release in Complex Food Systems,” Food and Bioprocess Technology, 18(12), pp. 10406–10418. Available at: https://doi.org/10.1007/s11947-025-04026-x.
Zadeike, D. et al. (2024) “Exploring Calcium Alginate-Based Gels for Encapsulation of Lacticaseibacillus paracasei to Enhance Stability in Functional Breadmaking,” Gels, 10(10), p. 641. Available at: https://doi.org/10.3390/gels10100641.
Zeng, Q. et al. (2025) “Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy,” European Journal of Medical Research, 30(1). Available at: https://doi.org/10.1186/s40001-025-02788-w.
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